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KMID : 0620920090410080548
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Experimental & Molecular Medicine
2009 Volume.41 No. 8 p.548 ~ p.554
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Cordycepin inhibits UVB-induced matrix metalloproteinase expression by suppressing the NF-κB pathway in human dermal fibroblasts
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Lee Young-Rae
Noh Eun-Mi
Jeong Eun-Yong
Yun Seok-Kweon
Jeong Young-Ju
Kim Jong-Hyeon
Kwon Kang-Beom
Kim Byeong-Soo
Lee Sung-Ho
Park Chang-Sik
Kim Jong-Suk
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Abstract
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Cordycepin (3’-deoxyadenosine) has been shown to exhibit many pharmacological activities, including anti- cancer, anti-inflammatory, and anti-infection activities. However, the anti-skin photoaging effects of cordycepin have not yet been reported. In the present study, we investigated the inhibitory effects of cordycepin on matrix metalloproteinase-1 (MMP-1) and -3 expressions of the human dermal fibroblast cells. Western blot analysis and real-time PCR revealed cordycepin inhibited UVB-induced MMP-1 and -3 expressions in a dose-dependent manner. UVB strongly activated NF-κB activity, which was determined by IκBα degradation, nuclear localization of p50 and p65 subunit, and NF-κB binding activity. However, UVB-induced NF-κB activation and MMP expression were completely blocked by cordycepin pretreatment. These findings suggest that cordycepin could prevent UVB-induced MMPs expressions through inhibition of NF-κB activation. In conclusion, cordycepin might be used as a potential agent for the prevention and treatment of skin photoaging.
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KEYWORD
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cordycepin, matrix metalloproteinases, NF-κB, skin aging, ultraviolet rays
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